ISTH News  49 Total

Scientific News  20 Total

Low-dose emicizumab versus low-dose factor VIII secondary prophylaxis for noninhibitor hemophilia A patients with severe bleeding phenotype

Low-dose emicizumab versus low-dose factor VIII secondary prophylaxis for noninhibitor hemophilia A patients with severe bleeding phenotype

June 26, 2024 | Nuchanan Kessakorn, M.D.; King Chulalongkorn Memorial Hospital; Bangkok, Thailand
Red blood cell-derived semaphorin 7A promotes arterial thrombosis via platelet integrin αIIb

Red blood cell-derived semaphorin 7A promotes arterial thrombosis via platelet integrin αIIb

June 25, 2024 | Chaojun Tang, Ph.D.; Soochow University; Su Zhou, Jiang Su Province, China
Prediction of anticoagulant-related bleeding in patients with cancer-associated thrombosis

Prediction of anticoagulant-related bleeding in patients with cancer-associated thrombosis

June 25, 2024 | Kristen Sanfilippo, M.D., M.P.H.S.; Washington University St. Louis School of Medicine; St. Louis Veterans Administration Medical Center; St. Louis, MO, U.S.


Development of antibodies to disrupt FXIII/fibrinogen interactions for venous thrombosis prevention

Development of antibodies to disrupt FXIII/fibrinogen interactions for venous thrombosis prevention

June 24, 2024 | Kadri Kangro, Ph.D.; University of North Carolina; Chapel Hill, NC, U.S.

G6b-B bi-specific cis-acting platelet receptor inhibitors (CAPRIs) – a novel therapy in thrombosis

G6b-B bi-specific cis-acting platelet receptor inhibitors (CAPRIs) – a novel therapy in thrombosis

June 24, 2024 | Amrita Sarkar, Ph.D.; Children’s Hospital of Philadelphia; Philadelphia, PA, U.S.
Receptor-bound plasminogen impacts on early platelet deposition and fibrin accumulation

Receptor-bound plasminogen impacts on early platelet deposition and fibrin accumulation

June 24, 2024 | Claire Whyte, Ph.D., B.Sc.; University of Aberdeen; Aberdeen, U.K.
Using artificial intelligence to disrupt the VWF-GPIBα interaction in platelet-type von Willebrand disease

Using artificial intelligence to disrupt the VWF-GPIBα interaction in platelet-type von Willebrand disease

June 23, 2024 | Thomas David Daniel Kazmirchuk, Ph.D.; Carleton University; Ottawa, Canada
Use of global coagulation assays to predict spontaneous major bleeding in chronic kidney disease patients

Use of global coagulation assays to predict spontaneous major bleeding in chronic kidney disease patients

June 23, 2024 | Rowena Brook, M.B.B.S.; Northern Health; Melbourne, Australia


Novel FVIIIa-mimetic molecule with the potential to be the first oral treatment for severe hemophilia A

Novel FVIIIa-mimetic molecule with the potential to be the first oral treatment for severe hemophilia A

June 23, 2024 | Jacob Lund, Ph.D.; Novo Nordisk A/S; Bagsvaerd, Denmark
Canonical and non-canonical FXII functions synergistically drive ovarian cancer-associated thrombosis and tumor progression

Canonical and non-canonical FXII functions synergistically drive ovarian cancer-associated thrombosis and tumor progression

June 23, 2024 | Dillon Bohinc, B.S.; Case Western Reserve University; Cleveland, OH, U.S.
EMA601, a novel humanized fab inhibits platelet glycoprotein VI with unprecedented potency and protects mice from arterial thrombosis and ischemic stroke

EMA601, a novel humanized fab inhibits platelet glycoprotein VI with unprecedented potency and protects mice from arterial thrombosis and ischemic stroke

June 23, 2024 | Stefano Navarro, Ph.D.; University of Wuerzburg; Wuerzburg, Germany; and Bernhard Nieswandt, Ph.D.; University of Wuerzburg and Emfret Analytics GmbH; Wuerzburg, Germany; Eibelstadt Germany
Fibrinogenγ390-396A protects against high fat diet-induced obesity and MASLD by altering glycine metabolism

Fibrinogenγ390-396A protects against high fat diet-induced obesity and MASLD by altering glycine metabolism

June 23, 2024 | Woosuk Steve Hur, Ph.D.; University of North Carolina at Chapel Hill; Chapel Hill, NC, U.S.

Evaluation of recombinant human prourokinase in the treatment of acute pulmonary embolism (ERUPTE): a randomized single-blinded multicenter phase 2 trial

Evaluation of recombinant human prourokinase in the treatment of acute pulmonary embolism (ERUPTE): a randomized single-blinded multicenter phase 2 trial

June 23, 2024 | Zhi-Cheng Jing, M.D.; Guangdong Provincial People's Hospital; Guangzhou, China; and Chun-Yan Cheng, M.D., Ph.D.; Guangdong Provincial People's Hospital; Guangzhou, China
Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa

Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa

June 22, 2024 | Fatma Işık Üstok, Ph.D.; University of Cambridge; Cambridge, U.K.